Vivitra 150mg injection| Trastuzumab Uses & Side effects

VIVITRA 150MG

DESCRIPTION

Vivitra 150mg injection be expressed by a targeted cancer drug known as Trastuzumab, which is Pharmacologically classify as humanized monoclonal antibody produced by recombinant DNA technology. Vivitra 150mg helps to decrease the rate of reactivation & mortality.

One of the epidermal growth factor receptors is known as human epidermal growth factor receptor 2 (HER2) plays vital role in breast cancer. This factor is responsible for cell replication.

An FDA approved product Vivitra 150mg injection which is involved in breast cancer treatment.

Vivitra 150mg injection vial with 858mg of lyophilized powder containing 150mg of Trastuzumab

vivitra 150mg

breast cancer

INDICATION

The drug Vivitra 150mg injection is used for the treatment of Supportive treatment for breast cancer
The drug Vivitra 150mg injection is used for the treatment of Advanced breast cancer
The drug Vivitra 150mg injection is used for the treatment of Advanced gastric cancer

MECHANISM

Vivitra 150mg is a type of monoclonal antibody which targeting the HER2, provoke a resistant mediate reaction which causes disguise and down regulation of HER2.
HER2 pathway is specific for cell proliferation, joining of Transtuzumab to the site of HER2 causes prevention of this activity.
This joining leads to antibody mediated and leads to HER2 positive cells break down.
Vivitra 150mg is an intermediary of anti-body dependent cellular cytotoxicity.

PRODUCT DETAILS

Brand : Vivitra
Ingredients : Trastuzumab
Strength : 150mg
Manufactured : Zydus Cadila
Package : 1 injection in 1 vial

PHARMACOKINETICS

DISTRIBUTION

Volume of distribution: 44 mL/kg as trastuzumab; 3.13 L as trastuzumab emtansine.

METABOLISM

As trastuzumab emtansine: which Undergoes deconjugation and catabolism through proteolysis in cellular lysosomes.

EXCRETION

Terminal Elimination half-life is 6 days (weekly dosing); 16 days (3 weekly regimen); approx. 4 days as trastuzumab emtansine.
Elimination of drug includes clearance of IgG through the reticuloendothelial system.

DOSAGE MANAGEMENT

Adjuvant regimen for HER2 over expressing Breast cancer:
52 weeks of treatment total schedules as follows:
• Combination With paclitaxel or docetaxel, over a 90 minutes, 4mg/kg IV then over 30 minutes, 2mg /kg for 12 weeks or combination with Carboplatin/ docetaxel for 18 weeks one week following the last weekly dose.
• Over 30 to 90 minutes, 6mg/kg IV for every 3 weeks.
Esophageal carcinoma or gastric cancer for adult dose:
• 8mg/kg IV over 90 minutes as initial dose
• 6mg/kg IV over 30 to 90 minutes for every 3 weeks as maintenance dose
• Duration of therapy for initial and maintenance dose until disease progression.
Breast cancer Metastatic HER2-Overexpressing:
• Over 90 minutes, 4mg/kg alone or with combination of paclitaxel in initial dose.
• Over 30 minutes, 2mg /kg once in a week for maintenance dose.
• Duration of therapy for initial and maintenance dose until disease progression.
Administration:
Vivitra 150mg injection is administer into vein through IV infusion over 90 minutes
Do not administer IV push or bolus.
Duration of vivitra 150mg is administrated in once every week or every 3 weeks.
Before starting treatment, patients should undergo biopsy to check Vivitra 150mg injection is the right regimen the infusion solution should be compatible to polyvinyl chloride or polyethylene bags.
After dilution, the infusion bag should be stored at 2oC to 8oC for not more than 24 hours before use.

PRECAUTIONS

Embryo fetal damage;
Vivitra 150mg is contraindicated to pregnancy period.
Avoid becoming pregnancy during this therapy.
Use efficient contraceptives during treatment
Cardiomyopathy;
Vivitra 150mg injection receiving patients have increased risk of exposing to cardiac disorders.
Provide alternative therapy management
In serious condition, treatment should be discontinuing
Pulmonary toxicity;
Some serious fatal cases of pulmonary toxicity occur during Vivitra 150mg injection treatment.
Infusion reactions;
During Vivitra 150mg treatment some life-threatening infusion reactions are produced.
In serious infusion reactions, Stop the Vivitra 150mg treatment permanently.
Patient should be treated with premedication before starting the infusion to overcome the such problem,
During Vivitra 150mg injection treatment. Use with Caution.
Therapy induced neutropenia;
Higher incidence of neutropenia occurs during Vivitra 150mg treatment.

SIDE EFFECTS

The most common adverse effects;
Cardiomyopathy, Infusion reactions, Embryo fetal toxicity, Pulmonary toxicity, Chemotherapy induced neutropenia. The most common side effects;
Hypertension, Influenza, Dyspnea, URI, Rhinitis, Pharyngolaryngeal pain, Sinusitis, Epitasis, Pulmonary hypertension, Dizziness, Decrease LVEF, Palpitations, Arrhythmia, Cardiac failure, Cough, Interstitial pneumonitis, Diarrhea/constipation, Nausea, vomiting, Dyspepsia, Autoimmune thyroiditis, Neutropenia, Hypokalemia, Anemia, Thrombocytopenia, Febrile neutropenia, Renal failure, Abdominal pain, Arthralgia, Back pain, Bone pain, Headache, Paresthesia, Rash, Nail disorders, Pruritus, Pyrexia, Chills, Edema, Asthenia, Sudden death.

PREGNANCY:

Vivitra 150mg injection pregnancy category is D: Vivitra 150mg should not suggest during pregnancy condition.

LACTATION :

Breast feeding should not be recommended.

STORAGE :

Vivitra 150mg injection vials should be stored at refrigerator temperature of 2°C to 8°C

Keep the vial away from heat & light
After reconstitution, vial should be stored at 2°C to 8°C for 28 days.
Stored vivitra 150mg injection diluted bag at 2°C to 8°C for 24 hours

MISSED DOSE:

If missed cycles of Vivitra 150mg treatment by one week or less, then the repeated maintenance dose (weekly schedule: 2mg/kg; 3 weekly schedules: 6mg/kg) administer as soon as probably.
Until the next planned cycle, the patient does not take interval.
Consecutive Vivitra 150mg injection maintenance dose should be taken in 7 days or 21 days next confer to the weekly or 3 weekly schedules.
If patient missed to take Vivitra 150mg dose by higher than one week, then resume with re-storing dose of Vivitra 150mg such as weekly schedule is 4mg/kg; 3 weekly schedules is 8mg/kg should be administered over period of 90 minutes.

CONTACT DETAILS

EMAIL:         millionhealthpharmaceuticals@gmail.com

PHONE NO: +91-9940472902

WEBSITE:    https://millionpharma.com/vivitra-150mg.php