Alecensa 150mg | Alectinib | MHP
ALECENSA 150MG
DESCRIPTION
Alecensa 150mg consist of second-generation anaplastic lymphoma kinase (ALK) inhibitor authorized by the US Food and Drug Administration to cure crizotinib-refractory non-small cell lung cancerAlecensa 150mg capsule inhibits the developments of cancer cells which are then damaged by the body
Alecensa 150mg which is used asprescription drug under the supervision of medical oncologist.
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| alecensa 150mg |
INDICATION
Alecensa 150mg capsule is prescribed for the therapy in patientsaffected by anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).MECHANISM OF ACTION
ALK is a family of proteins known as receptor tyrosine kinases (RTKs), which are included in the growth of cells and the development of new blood vessels which supply them. In patients with ALK-positive NSCLC, an abnormal form of ALK is formedwhichencourage the cancer cells to multiply and grow in an uncontrolled fashion. The active substance in Alectinib, is an ALK inhibitor and acts by stopping the action of ALK, thereby decreasing the growth and spread of the cancer.PRODUCT DETAILS
Brand :AlecensaIngredients : Alectinib
Strength : 150mg
Manufactured : Genentech, Inc
Package : 240 capsules
ADME
Highplasma concentration 4 hours and bioavailability of Alecensa 37%
Humanplasma proteins binding is 99%
The drug Alecensa 150mg capsule has Metabolized by CYP3A4 to its major active metabolite M4, the main circulating moieties in plasma, total radioactivity 76% constituting.
In oral administration, radioactivity 98% was eliminated in feces. dose was excreted in the feces unchanged Alectinib is 84%. Half-life is 33 hours
The prescribed dose is 600mg PO BID until disease progression or unacceptable
Renal impairment patient’s prescribed dose is 450mg orally twice in a day
Alecensa 150mg capsule is administrated with food.
While on treatment withAlecensa will causes Symptomatic bradycardia; control heart rate and blood pressure regularly.
Alecensa 150mg capsule treatment may causes severemuscle pain and elevated CPK resulted; advise patients to report any unexplained muscle pain, tenderness, or weakness;
During Alecensa 150mg treatmentRenal impairment occurred; incidence of Grade ≥3 renal impairment was 1.7%, of which 0.5% were fatal events.
Serious side effects :
Anemia, Fatigue, Liver problems, Hyperglycaemia, Constipation, Hypercalcemia, Muscle and bone pain, Edema, Low potassium.
The drug Alecensa 150mg capsule has Metabolized by CYP3A4 to its major active metabolite M4, the main circulating moieties in plasma, total radioactivity 76% constituting.
In oral administration, radioactivity 98% was eliminated in feces. dose was excreted in the feces unchanged Alectinib is 84%. Half-life is 33 hours
DOSAGE MANAGEMENT
Non- Small Cell Lung Cancer :The prescribed dose is 600mg PO BID until disease progression or unacceptable
Renal impairment patient’s prescribed dose is 450mg orally twice in a day
Alecensa 150mg capsule is administrated with food.
PRECAUTIONS
When administered to pregnant womenEmbryo-fetal toxicity resulted: Based on data from animal studies and its mechanism of action, Alecensa 150mg can cause fetal harm.While on treatment withAlecensa will causes Symptomatic bradycardia; control heart rate and blood pressure regularly.
Alecensa 150mg capsule treatment may causes severemuscle pain and elevated CPK resulted; advise patients to report any unexplained muscle pain, tenderness, or weakness;
During Alecensa 150mg treatmentRenal impairment occurred; incidence of Grade ≥3 renal impairment was 1.7%, of which 0.5% were fatal events.
SIDE EFFECTS
Alecensa 150mg capsule has some side effects while administrating certain condition as follows :
COMMON SIDE EFFECTS :
Muscle pain, Bradycardia, Tiredness, Constipation, Anemia , Hepatotoxicity, Trouble breathing, Shortness of breath , Cough, Fever .Serious side effects :
Anemia, Fatigue, Liver problems, Hyperglycaemia, Constipation, Hypercalcemia, Muscle and bone pain, Edema, Low potassium.
PREGNANCY
Pregnancy Category D: Based on studies of animal and pharmacological action, Alecensa 150mg will cause fetal harm when given to pregnant womenWhile on treatment with Alecensa 150mg capsule tell the female not to become pregnant
LACTATION
While on treatment with Alecensa 150mg, discuss with the women not to breastfed to infantsSTORAGE
Store at below 30°CKeep the drug in its original container.
MISSED DOSE
If the patient missed to take a dose, then should not to take an extra dose, but before taking the next dose, have the missed dose at the regular time, leave the missed dose. Consult the doctor
CONTACT DETAILS
EMAIL :millionhealthpharmaceuticals@gmail.com
PHONE NO :+91-9940472902
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