Jakavi 20mg tablets |Ruxolitinib | MHP

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JAKAVI 20MG

DESCRIPTION

Jakavi 20mg belongs to the classification of medications called anti-cancer drugs.
Jakavi 20mg tablet is a Janus kinase inhibitor with discrimination for subtypes JAK1 and JAK2 of this enzyme. Jakavi 20mg prohibits dysregulated JAK signaling along with myelofibrosis. This regimen is not prescribed for use in patients below 18 years of age.
Jakavi 20mg tablet is prescription drug provided under supervision of medical oncologist.
jakavi 20mg tablet
jakavi 20mg

MECHANISM OF ACTION

Ruxolitinib is also known as targeted treatment which targets and joints to the tyrosine kinase receptors and prohibits Janus Associated Kinases (JAK1 and JAK2) which Intercede the signaling of several cytokines and growth factors which are important for hematopoiesis and immune function. By irrevocable to these receptors, Ruxolitinib stops important pathways which develop cell division. Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) known to be analogue with dysregulated JAK1 and JAK2 signaling. Patients with MF who either carry the JAK2 V617 mutation or does not have the JAK2 V617F mutation may both respond to Ruxolitinib.

PRODUCT DERTAILS

Brand :Jakavi
Ingredients : Ruxolitinib
Strength : 20mg
Manufactured : Novartis Ltd
Package : Strips of 14 tablets

ADME

Absorption:
Rapid absorption and not affected by food maximum plasma level is 1.5 hours.
Distribution:
Volume of distribution is 76.6 L plasma protein binding is 97%
Metabolism:
metabolized by CYP3A4
Elimination:
Excreted via urine 74% and unchanged drug is <1% and through urine 22%, <1 % as unchanged drug

DOSAGE MANAGEMENT

Myelofibrosis :
Starting recommended doses for myelofibrosis
If Platelet count >200 x10^9/L the prescribed dose is 20 mg PO BID
If Platelet count 100-200 x10^9/L the prescribed dose is 15 mg PO BID
If Platelet count 50 to <100 x10^9/L the prescribed dose is 5 mg PO BID
Titrate dose based on response; not to exceed 25 mg PO BID
Polycythemia Vera :
The prescribed dose is 10mg PO BID
Undergo CBC and platelet count prior starting and q2-4wk until doses are stabilized, and then as clinically used.

PRECAUTIONS

Progressive multifocal leukoencephalopathy (PML) has occurred with Jakavi 20mg treatment. If PML is suspected, discontinue Jakavi 20mg tablet and evaluate.
Non-melanoma skin cancers including basal cell, squamous cell, and Merkel cell carcinoma have resulted in patients administrated with Jakavi 20mg. Do the periodic skin examinations.
Therapy with Jakavi 20mg tablet can resulted in thrombocytopenia, Anemia and neutropenia. Regulate thrombocytopenia by decreasing the dose or temporarily prohibit Jakavi 20mg. Platelet transfusions may be needed.
Risk of infection occurs by delay initiate treatment with Jakavi 20mg tablet until active serious infection have resolved.
Tuberculosis infection has been resulted in patients administrating Jakavi 20mg. monitor patients getting Jakavi 20mg tablet for signs and symptoms of active tuberculosis and manage promptly.

SIDE EFFECTS

• Cholesterol level increased
• Dyspnea
• Nasopharyngitis
• Headache
• Constipation
• Decreased RBC
• Reduce in platelet counts
• Nausea & Vomiting
• Sleeplessness
• Liver enzymes increased
• Diarrhea
• bleeding
• Swelling
• Neutropenia
• Dizziness

PREGNANCY

The drug has no studies with the Jakavi 20mg use in pregnant women to inform drug-along with risks. Hence avoid becoming pregnancy during Jakavi 20mg tablet treatment

LACTATION

Avoid breastfeeding to infants during treatment with Jakavi 20mg. Excretion into human milk is unknown

STORAGE

Jakavi 20mg tablet stored at 20°C to 25°C
Protect away from light and moisture
Dispense in its original container

CONTACT DETAILS
EMAIL:           millionhealthpharmaceuticals@gmail.com
PHONE NO:   +91-9940472902







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