Tasigna 150mg - Anticancer drugs | view uses, side effects and price | MHP
NILOTINIB 150MG
DESCRIPTION
Nilotinib sold under the brand name Tasigna 150mg tablet and its belongs to targeted cancer cells Tasigna is anticancer drugs, which prohibits development of the cancer cells.Tasigna 150mg is a prescription medicine, which sold under the supervision of medical oncologist. Tasigna 150mg is also belongs to the class of kinase inhibitors.
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| tasigna 150mg |
TASIGNA INDICATION
Tasigna 150mg tablets is mainly indicated in the conditions like; Chronic and accelerated phase Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) resistant or intolerant to prior therapy that included Imatinib in adult patientsMECHANISM OF ACTION
CML: chronic myelogenous leukemia is caused by BCR-ABL oncogene Tasigna 150mg (nilotinib) is a kinase inhibitor, which prohibits BCR-ABL kinase activity. Tasigna 150mg tablet link to the ATP-bounding site of BCR-ABL protein Tasigna 150mg inhibits proliferation of murine leukemic cell lines and human cell lines derived from patients with Philadelphia positive CMLPHARMACOKINETIC
ABSORPTION
The bioavailability of Tasigna 150mg tablets are about 50% The time to high plasma concentration of Tasigna 150mg tablet is occurred within 3 hours after administration.EFFECT OF FOOD
The effect of drug is increased to 82% when the dose was given 30 minutes after a high fat meal when compared to fasted patient.DISTRIBUTION
The binding of serum protein of the Tasigna 150mg is approximately 98% The drug nilotinib blood plasma ratio is 0.68METABOLISM
Tasigna 150mg tablet is metabolized through CYP3A4 mediated oxidation Tasigna 150mg is the prime flowing component in the blood streamELIMINATION
The Tasigna 150mg tablet half life period is approximately 17 hours
PRODUCT FDETAILS
Ingredients : Nilotinib
Strength : 150mg
Category : Anti-neoplastic drug
DOSAGE MANAGEMENT
The usual dose of Tasigna 150mg Tablet should be taken as two times in a day at time intervals of 12 hours. The tablet Tasigna 150mg administrated on an empty stomach. Food should not be taken for at least 1 hour after the dose is taken or 2 hours before the dose is taken
Tasigna 150mg capsules, should be dispersed in one teaspoon of applesauce for the patients, who are unable to taken through mouth Immediately within 15 minutes this mixture should be taken . concomitant use with hematopoietic growth factors such as erythropoietin or G-CSF is mandatory Also with hydroxyurea or anagrelide
DOSAGE IN ADULT PATIENTS WITH PHILADELPHIA POSITIVE CML-CP
The usual dose of the Tasigna 150mg tablet in this condition is 300mg should be given orally as twice daily.WITH RESISTANT OR INTOLERANT PHILADELPHIA POSITIVE CML-CP AND CML-AP
The recommended dose is 400mg should be administered as orally twice dailyIN PEDIATRICS
The usual dose for child 230mg/m2 should be administred orally twice daily The maximum dose of Tablet Tasigna 150mg is 400mg.
SIDE EFFECTS
TASIGNA SIDE EFFECTS
SKIN
Rash, Pruritus, alopecia, dry skin
GIT
Nausea, constipation, diarrhea, vomiting, upper abdominal pain, dyspepsia
Nausea, constipation, diarrhea, vomiting, upper abdominal pain, dyspepsia
NERVE SYSTEM
Headache, dizziness
Headache, dizziness
GENERAL
Fatigue, pyrexia, asthenia, peripheral edema, face edema
Fatigue, pyrexia, asthenia, peripheral edema, face edema
MUSCLE
Myalgia, arthralgia, muscle spasm, pain in extremity, back pain
Myalgia, arthralgia, muscle spasm, pain in extremity, back pain
PULMONARY
Cough, oropharyngeal pain, dyspnea
INFECTIONS & INFESTATIONS
Nasopharyngitis, upper respiratory tract infection, influenza, gastroenteritis
Nasopharyngitis, upper respiratory tract infection, influenza, gastroenteritis
EYE
Eyelid edema, periorbital edema
Eyelid edema, periorbital edema
PSYCHIATRIC
Insomnia
Insomnia
VASCULAR
Hypertension
PREGNANCY & LACTATION
Pregnancy category: D Tasigna 150mg tablet avoid during pregnancy condition and women who become pregnant Tasigna 150mg not recommended in breastfeeding mothers
Hypertension
PREGNANCY & LACTATION
Pregnancy category: D Tasigna 150mg tablet avoid during pregnancy condition and women who become pregnant Tasigna 150mg not recommended in breastfeeding mothers
STORAGE
Stored at 68°F to 77°F (20°C to 25°C) keep the cartoon away from heat, moisture and light
MISSED DOSE
If patients missed to take the dose of Tasigna should be take within the time, or the missed dose should be skipped and follow the next dosing schedule.
CONTACT DETAILS
EMAIL: millionhealthpharmaceuticals@gmail.com
PHONE NO :+91-9940472902
WEBSITE : https://millionpharma.com/nilotinib-150mg.php
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