Tasigna 200mg - Anticancer drugs | view uses, side effects and price | MHP
NILOTINIB 200MG
DESCRIPTION
Nilotinib sold under the brand name Tasigna 200mg and its belongs to targeted cancer cells Tasigna 200mg tablet is anticancer drugs, which prohibits development of the cancer cells.Tasigna 200mg tablet is a prescription medicine, which sold under the supervision of medical oncologist. Tasigna 200mg tablet is also belongs to the class of kinase inhibitors.
TASIGNA 200mg |
TASIGNA INDICATION
Tasigna 200mg tablet is mainly indicated in the conditions like; Chronic and accelerated phase Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) resistant or intolerant to prior therapy that included Imatinib in adult patientsMECHANISM OF ACTION
CML: chronic myelogenous leukemia is caused by BCR-ABL oncogene Tasigna 200mg(nilotinib) is a kinase inhibitor, which prohibits BCR-ABL kinase activity. Tasigna 200mg link to the ATP-bounding site of BCR-ABL protein Tasigna 200mg tablet inhibits proliferation of murine leukemic cell lines and human cell lines derived from patients with Philadelphia positive CMLPHARMACOKINETIC
ABSORPTIONThe bioavailability of Tasigna 200mg tablets are about 50% The time to high plasma concentration of Tasigna 200mg tablet is occurred within 3 hours after administration.
EFFECT OF FOOD
The effect of drug is increased to 82% when the dose was given 30 minutes after a high fat meal when compared to fasted patient.
DISTRIBUTION
The binding of serum protein of the Tasigna 200mg is approximately 98% The drug nilotinib blood plasma ratio is 0.68
METABOLISM
Tasigna 200mg tablet is metabolized through CYP3A4 mediated oxidation Tasigna 200mg is the prime flowing component in the blood stream
ELIMINATION
The Tasigna 200mg half life period is approximately 17 hours
PRODUCT DETAILS
Ingredients : NilotinibStrength : 200mg
Category : Anti-neoplastic drug
DOSAGE MANAGEMENT
The usual dose of Tasigna 200mg tablet should be taken as two times in a day at time intervals of 12 hours. The tablet Tasigna 200mg administrated on an empty stomach. Food should not be taken for at least 1 hour after the dose is taken or 2 hours before the dose is taken
Tasigna 200mg capsules, should be dispersed in one teaspoon of applesauce for the patients, who are unable to taken through mouth Immediately within 15 minutes this mixture should be taken . concomitant use with hematopoietic growth factors such as erythropoietin or G-CSF is mandatory Also with hydroxyurea or anagrelide
SIDE EFFECTS
TASIGNA SIDE EFFECTS
SKIN
Rash, Pruritus, alopecia, dry skin
GIT
Nausea, constipation, diarrhea, vomiting, upper abdominal pain, dyspepsia
Nausea, constipation, diarrhea, vomiting, upper abdominal pain, dyspepsia
NERVE SYSTEM
Headache, dizziness
Headache, dizziness
GENERAL
Fatigue, pyrexia, asthenia, peripheral edema, face edema
Fatigue, pyrexia, asthenia, peripheral edema, face edema
MUSCLE
Myalgia, arthralgia, muscle spasm, pain in extremity, back pain
Myalgia, arthralgia, muscle spasm, pain in extremity, back pain
PULMONARY
Cough, oropharyngeal pain, dyspnea
INFECTIONS & INFESTATIONS
Nasopharyngitis, upper respiratory tract infection, influenza, gastroenteritis
Nasopharyngitis, upper respiratory tract infection, influenza, gastroenteritis
EYE
Eyelid edema, periorbital edema
Eyelid edema, periorbital edema
PSYCHIATRIC
Insomnia
Insomnia
VASCULAR
Hypertension
DOSAGE IN ADULT PATIENTS WITH PHILADELPHIA POSITIVE CML-CP
The usual dose of the Tasigna 200mg tablet in this condition is 300mg should be given orally as twice daily.
WITH RESISTANT OR INTOLERANT PHILADELPHIA POSITIVE CML-CP AND CML-AP
The recommended dose is 400mg should be administered as orally twice daily
IN PEDIATRICS
The usual dose for child 230mg/m2 should be administred orally twice daily The maximum dose of Tablet Tasigna 200mg is 400mg.
Hypertension
DOSAGE IN ADULT PATIENTS WITH PHILADELPHIA POSITIVE CML-CP
The usual dose of the Tasigna 200mg tablet in this condition is 300mg should be given orally as twice daily.
WITH RESISTANT OR INTOLERANT PHILADELPHIA POSITIVE CML-CP AND CML-AP
The recommended dose is 400mg should be administered as orally twice daily
IN PEDIATRICS
The usual dose for child 230mg/m2 should be administred orally twice daily The maximum dose of Tablet Tasigna 200mg is 400mg.
CONTACT DETAILS
EMAIL: millionhealthpharmaceuticals@gmail.com
PHONE NO: +91-9940472902
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